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Urology/Renal Function
Renal Malfunction Differential Diagnosis:Urine and serum osmolality respond differently to water overload, water deprivation, diuretics, antidiuretic hormone (ADH) and insulin.
Uremia: The difference between measured and calculated osmolalities can determine the accumulation of unmeasured metabolites in the blood. Once baseline electrolyte levels are established, osmolality can be used to monitor the progress of the uremic patient.
Osmolal & Free Water Clearance: Clearance can be calculated immediately from urine and serum osmolality, providing the earliest marker of tubular damage.
Renal Dialysis: In patients with known
renal disease, elevated serum osmolality can indicate the need for dialysis.
During therapy, dialystate osmolality can be used to monitor progress.